Special Issue: Bioelectricity of the Tumor Microenvironment
Dr. Paul Buchanan
Dublin City University, Ireland
Prof. Christophe Vandier
University of Tours, France
Tumors are composed of a heterogenous cell population alongside a vast array of chemical mediators, extracellular fluids and matrix proteins, which collective interact and form the tumor microenvironment (TME). The resultant TME has been shown to support not only neoplastic development and progression but also treatment resistance. Bioelectricity is involved in the normal functioning of the various cell populations and its disruption contributes to the deleterious effects of the TME on cancer.
This Special Issue focuses on the cellular architecture of the TME, in addition to cancer cells, in particular, stem, immune, stromal and endothelial cells. Intended manuscripts will aim at exploring the impact of aberrant bioelectrical signaling within the TME as a whole in promoting tumorigenesis. Articles should highlight the importance of bioelectric targets as potential novel personalized cancer therapeutics with a view to improving patient outcomes.
The guest editors would welcome original research articles, reviews, perspectives, technical notes and protocols that report on recent advances in the field. Areas of interest include, but are not restricted to:
- Cancer development and progression
- Cancer stem cells
- Immune cells and signaling
- Stromal interactions
- Ion channels, exchangers, pumps, receptors
- Cell signaling
- Extracellular matrix
Contributions will receive prompt and thorough peer review. Please refer to our Instructions for Authors before submitting your manuscript for consideration. Also, before submitting, authors would be welcome to discuss their ideas directly with Guest Editors.
Early submissions will receive prompt and thorough peer-review; accepted manuscripts will be published as e-pub ahead of print when-ready.