Genetic and Non-Genetic Inflammation Networks in Major Human Diseases
Guest Editor
Yan Ma, PhD
National Institutes of Health
Decades of research have shown how the clinical manifestation of inflammation can also be pathological and prime the tissue niche for the progression of myriad complex diseases. Interestingly, several genome-wide association studies (GWAS), whole-exome sequencing (WES), and single cell-based technologies have highlighted how rare genetic mutations or variations modulate the susceptibility of an individual to infectious pathogens by influencing pathological inflammation at a genetic level. In addition to the genetic determinants, inflammation can also be triggered by multiple non-genetic factors including microbiome, toxic compounds, diet, and stress, which affects the epigenome and secretome of tissue microenvironment. Altogether, these genetic and non-genetic associations in inflammatory diseases have long been established in several clinical and epidemiological studies. However, we still lack a significant understanding of causal links and strategic explanations for the interaction between genome, epigenome, microbiome, metabolome, and inflammatome.
In this research topic, we welcome the submission of original articles, reviews, and perspectives regarding the genetic and non-genetic determinants in pathological inflammation. We aim to get a better understanding of mechanisms of inflammation and inflammatory responses in a variety of diseases and figure out molecular and computational methodologies to identify new genetic variants linked to the cause and consequences of inflammatory diseases.
This prominent special issue will consider articles from the full breadth of evidence: from original research papers and reviews, to perspectives, profiles, commentaries, and exemplary front matter.
Areas of interest include, but are not limited to:
- Mechanisms of inflammation and inflammatory response
- The interaction between genome, epigenome, microbiome, metabolome, and inflammatome
- Genetic drivers of progression, metastasis and therapeutic resistance to inflammatory diseases
- Molecular basis and regulation of inflammatory diseases
- Proinflammatory cytokines
- Genetic heterogeneity and lineage tracing
We also encourage submission of papers that have been published in conference proceedings, with the requirement that the authors have made significant extensions as compared to the already published version of the study.
Manuscript Submission Deadline: March 30, 2023
Questions or pre-submission queries? Please contact Guest Editor Dr. Yan Ma