Special Issue: A New Way of Thinking About Therapeutic Hypothermia
Co-Guest Editors
Travis C. Jackson, PhD
USF Health Heart Institute, Morsani College of Medicine
University of South Florida
Tampa, FL
W. Dalton Dietrich, PhD
Department of Neurological Surgery, The Miami Project to Cure Paralysis
University of Miami
Miami, FL
Recent advances on the cell signaling pathways modulated by hypothermia has spurred a research renaissance into novel molecular components mediating cooling-induced neuroprotection. In parallel with those discoveries, interest has surged for the development of novel pharmacological approaches to reproduce or augment a variety of molecular facets of hypothermia. In the face of these advances, the meaning of the term “therapeutic hypothermia” (TH) is rapidly evolving. However, our vocabulary to communicate nuanced discussions on the molecular complexity of cooling has not met pace with the velocity of research progress. In this special issue of Therapeutic Hypothermia & Temperature Management, we combine a traditional highlight of contemporary research on pharmacological methods for modulating TH, and overlay it with a thought-provoking new dialect to stimulate a broader discussion on the changing nature of TH in the clinic and to begin to articulate what it might mean both literally and figuratively for the neuro-ICU of tomorrow.
All manuscripts should be submitted online using the submission platform by September 21, 2020. All submissions will be subject to a rigorous peer review. We encourage submissions of original research articles, reviews, and perspectives.
Suggested topic areas include, among others:
- Drugs to induce endogenous hypothermia
- Drugs to mimic hibernation
- Drugs to modulate cold shock proteins
- In vitro or in vivo studies on the molecular mechanisms regulated by cold stress hormones in central nervous system cells
- In vitro or in vivo studies on the molecular mechanisms regulated by cold shock proteins in central nervous system cells
- Observational studies on the “molecular fingerprint” at different depths of hypothermia
- Observational studies on the “molecular fingerprints” of hibernating animals
Visit Therapeutic Hypothermia & Temperature Management online to learn more, read past issues, and view author submission guidelines. Queries to the editor to propose a topic prior to submission are encouraged. Please contact Managing Editor Helen Bramlett to initiate your query or for any further details.