Special Issue on Metabolism Impact on Immunotherapy
Guest Editor
Thomas Kieber-Emmons, PhD
Professor of Pathology
Wilkins Chair in Breast Cancer Research
Leader, Therapeutic Sciences Program
Winthrop P. Rockefeller Cancer Institute
University of Arkansas for Medical Sciences
Deadline for submission: September 1, 2018
Over the years we have come to realize that the metabolic landscape of the tumor microenvironment in which the nutrient/metabolite pools and environmental conditions have been dramatically altered by the metabolic state of tumors and the immune system. The impact of this collective metabolic state to support the oncogenic state requires metabolic reprogramming to meet the challenges of macromolecular synthesis. We now appreciate that the process of metabolic reprogramming in cancers is complex, driven by mutations and/or epigenetic alterations and modified by the cellular context, including interaction with other cells in the microenvironment. It is now also recognized that metabolic reprogramming confers metabolic liabilities, which can be exploited for the therapeutic targeting for cancer therapy. However, in order to capitalize on these advances to improve cancer immunotherapy we need to understand more fully how metabolic pathway choice affects lymphocyte differentiation into specific effector subsets and how the immune system is affected by the altered metabolic landscape of the tumor microenvironment.
This special issue calls on approaches that draw attention to topics that will help us to understand the similarities, differences, and functional consequences of the metabolic pathways utilized by activated immune cells and cancer cells that would guide the development of metabolic interventions to improve immunotherapy and how immunotherapy might influence metabolic reprogramming.
Monoclonal Antibodies in Immunodiagnosis and Immunotherapy provides targeted peer-reviewed research that advances the understanding of immune responses and the use of immunological methods for therapeutic purposes.
For this special issue, we are currently seeking high quality, innovative manuscripts that will contribute to the scientific literature of metabolism impact on immunotherapy. Submissions are accepted in the form of original research articles, review articles, mini-reviews, rapid communications, brief reports, perspectives, and commentary.
Topics for consideration for this special issue include, but are not limited to:
1. Approaches to reprogram the metabolic qualities of anti-tumor immune cells (either ex vivo or in vivo) to improve immunotherapy (homing, persistence and/or effector function)
2. Approaches that target cancer cell metabolic pathways to impair cancer cell survival without compromising endogenous anti-tumor immunity
3. Adaptive immunity in metabolic-related inflammation and markers of disease and immune response.
4. Metabolic Regulation of Lymphocytes
5. Epigenetic regulation of immune checkpoints
Deadline for submission: September 1, 2018
Advantages of publishing in Monoclonal Antibodies in Immunodiagnosis and Immunotherapy include:
• Fast and user-friendly electronic submission
• Rapid, high-quality peer review
• Maximum exposure: accessible in 170 countries worldwide
• Open Access options available