Precision Engineering of the Genome, Epigenome and Transcriptome - Over the last several years, new genome engineering tools have revolutionized the ability to interrogate biological systems, engineer innovative biotechnologies, and model and treat human disease. The genome engineering field continues to evolve at a frenzied pace, including both the development of new fundamental tools and their application to addressing societal needs. This Keystone Symposium will cover this spectrum of advances, including the most recent technological innovations in genome, epigenome, and transcriptome precision engineering. The conference will also highlight recent advances in developing human therapeutics with these tools, including emerging clinical trial results and preclinical examples of novel modes of intervention. The Symposium will include a variety of topics of interest to the broad research community, including next-generation applications such as high-throughput screening, synthetic biology, and chromatin and RNA imaging and diagnostics. Finally, the Symposium will conclude with examples of how emerging technologies can be integrated for an unprecedented level of resolution of cellular processes – such as genome engineering combined with single-cell analysis methods. Collectively, this meeting will build on its history of success by familiarizing the audience with the latest advances in tool development, providing an update on clinical application of these tools, and generating an appreciation for the breadth of scientific areas impacted by the Genome Engineering Revolution.
The CRISPR Journal is the only peer-reviewed publication dedicated to the science and applications of gene editing. Spearheaded by Editor-in-Chief Rodolphe Barrangou, PhD and aided by a diverse and accomplished editorial board, the Journal provides a high-profile forum for cutting-edge international original research papers, as well as a compelling mixture of frontmatter content— review articles, perspectives, profiles, and commentary spanning not only matters of research but the many social, ethical, and business issues confronting the field. The CRISPR Journal centralizes essential information and analysis on this revolutionary technology in a single location with the aim of solidifying and growing the community of innovative researchers, practitioners, policymakers, and activists who make up the field of gene editing.
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