Special Issue on Virus-Induced Programmed Cell Death
Dr. Rod Russell
Professor of Molecular Virology and Viral Immunology
Memorial University of Newfoundland
St. John’s, Newfoundland, Canada
To highlight the various types of virus-induced cell death, and to frame these in the context of how they affect the immune response against various viruses, Viral Immunology is organizing a Special Issue on Virus-Induced Programmed Cell Death.
We have known for decades that many viruses kill their host cells, and the discovery of programmed cell death, such as apoptosis, provided distinction from regular necrotic cell death. However, the study of virus-host interactions has since revealed a much broader picture, with numerous other forms of cell death having been observed in the context of numerous virus infections. We have seen that some viruses can cause cell death as mechanisms of pathogenesis, while others use induction of programmed cell death as a means to evade the immune system. The discovery of the inflammasome and the many components and pathways involved in inflammasome activation has helped to explain inflammatory forms of cell death, such as pyroptosis. Whether these forms of virus-induced cell death are mutually exclusive, or whether they undergo crosstalk, has also recently come to light with the description of PANoptosis.
We will consider manuscripts on the following topics:
- Virus-induced inflammasomes and inflammatory cell death
- Immunogenic cell death caused by viruses
- Viral inhibition of programmed cell death
- Vaccine-induced inflammasome activation
- Virus-induced inflammation
- Inhibition of virus-induced cell death
Viral Immunology delivers cutting-edge peer-reviewed research on rare, emerging, and under-studied viruses, with special focus on analyzing mutual relationships between external viruses and internal immunity. Original research, reviews, and commentaries on relevant viruses are presented in clinical, translational, and basic science articles for researchers in multiple disciplines. Viral Immunology is under the leadership of Dr. Rod Russell with the support of an international team of Editors.
Please address any questions to the Journal's Editor-in-Chief Dr. Rod Russell.